Compelling evidence suggests that both medications and therapeutic interventions are effective in the treatment of psychiatric disorders. The current “state of the science” involves multiple modalities to produce better outcomes than those observed using either psychopharmacology or therapy alone. Clinicians in all settings need to understand how various therapeutic interventions can profoundly influence clients’ ability to cope and change. Using the unifying framework developed by Hubble, Duncan, and Miller, we examine the four common elements that account for much of the improvement seen in clients, regardless of the approach taken. These constructs are applied to various simple, brief approaches that are easily enacted – and easily adapted – to any patient encounter.